Neurobiology of Disease The Ability of BDNF to Modify Neurogenesis and Depressive-Like Behaviors Is Dependent upon Phosphorylation of Tyrosine Residues 365/367 in the GABAA-Receptor 2 Subunit
نویسندگان
چکیده
Mansi Vithlani,1* Rochelle M. Hines,2* Ping Zhong,4* Miho Terunuma,2 Dustin J. Hines,2 Raquel Revilla-Sanchez,2 Rachel Jurd,2 Phillip Haydon,2 Maribel Rios,2 Nicholas Brandon,3 Zhen Yan,4 and Stephen J. Moss1,2 1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom, 2Department of Neuroscience, Tufts University, Boston, Massachusetts 02111, 3AstraZeneca Pharmaceuticals, Cambridge, Massachusetts 02139, and 4Department of Physiology and Biophysics, University at Buffalo, State University of New York, Buffalo, New York 14214
منابع مشابه
Prenatal stress increased γ2 GABAA receptor subunit gene expression in hippocampus and potentiated pentylenetetrazol-induced seizure in rats
Objective(s): Stress during pregnancy is able to bring extensive effects on neurobehavioral development in offspring. The GABAergic system plays a pivotal role in neuronal excitability, which can be affected by prenatal stress (PS). This study aimed to evaluate impact of the PS on γ2 subunit of gamma-aminobutyric acid A (GABAA) receptor gene expression in the hippocamp...
متن کاملP145: The Role of γ-Aminobutyric Acid Receptor in The Social Anxiety Disorder
Social anxiety disorder (SAD) is the one of the most common anxiety disorders. Despite its high prevalence, the disorder is still considerably undiagnosed and untreated. The disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (GABA) s...
متن کاملThe Health Impacts of Fasting During Ramadan
Ramadan is the Holy month of fasting that is obligatory for all normal Muslims who reached at their puberty. Two meals are taken during Ramadan, one is taken before down to prepare themselves for fast is called “Sahur”, and second meal is taken at sunset is called “Iftar”. Fasting is not only a ritual and religious obligation while it has several medicinal significances specia...
متن کاملO7: Functional Characterization of Human GABAA Autoantibodies in the Context of Limbic Encephalitis
Limbic encephalitis is an adaptive autoimmune disease, induced by different autoantibodies, which target extracellular neuronal epitopes, such as NMDA or GABAB receptors1,2. Recently our group found another human antibody, which binds to the α1 subunit of the GABAA receptor. Since the GABAA receptor is responsible for the majority of fast inhibitory neurotransmission, we investigated chan...
متن کاملQuantitative Analysis of GABAA Gamma Receptor Subunits in the Developing Embryonic Chick Forebrain
Objective(s) In this study we investigated the expression of GABAA receptor subunits during brain development. These receptors may change in the embryonic chick forebrain. Materials and Methodes The expression levels of four types of GABAA receptor gamma subunits (γ1, γ2, γ3 and γ4) were quantified in the embryonic chick forebrain at 32 hr, 3, 7, 14, and 20 days of incubation and day one aft...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013